Therefore, vit B 12 deficiency can lead to serious anemia, neuropathy and impaired brain function. It is the source of a coenzyme that participates in folate metabolism and thus plays a vital role in nucleotide synthesis ( 13). Vit B 12 is reported to attenuate neuronal degeneration. Vitamin B 12 (Vit B 12) is a water-soluble vitamin that possesses anti-inflammatory and analgesic pro-perties ( 12). No standard therapy is currently available to reverse METH’s neurotoxic effects ( 11). It seems that different mechanisms are involved in METH- induced neurotoxicity like generation of reactive oxygen/nitrogen species, glutathione depletion and cell death ( 10). Direct effects of METH on the brain can induce neurological deficits via chemical and molecular changes that may lead to serious health hazard ( 9). Pharmacological and psychological effects of amphetamine derivatives are due to enhanced neurotransmitters (serotonin, dopamine, and norepinephrine) release from nerve endings ( 8). METH also affects the cardiovascular system and increases blood pressure, heart rate and risk for stroke and heart attack ( 7). Even in small amounts, METH can lead to loss of appetite, increase in physical activity, confusion and produce wakefulness and euphoria ( 6). METH abuse can adversely affect health and cause long-term complications ( 4, 5). METH rapidly crosses the blood brain barrier and penetrates into the brain and CSF. METH use in the treatment of attention deficit hyperactivity disorder in children and also in short term use in obesity has been approved by the FDA ( 3). METH can be snorted, smoked, injected or taken orally for therapeutic and recreational purposes. Relative ease of access and low cost of synthesis are among the reasons that METH abuse is on the rise ( 1, 2). Methamphetamine (METH) (also called meth, speed, chalk, crystal, and ice among other common slang terms) is a powerful stimulant drug with chemical structure similar to amphetamine.
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